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Primary immune responses are negatively impacted by persistent herpesvirus infections in older people: results from an observational study on healthy subjects and a vaccination trial on subjects aged more than 70 years old

BACKGROUND: Advanced age is accompanied by a decline of immune functions, which may play a role in increased vulnerability to emerging pathogens and low efficacy of primary vaccinations in elderly people. The capacity to mount immune responses against new antigens is particularly affected in this po...

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Detalles Bibliográficos
Autores principales: Nicoli, Francesco, Clave, Emmanuel, Wanke, Kerstin, von Braun, Amrei, Bondet, Vincent, Alanio, Cécile, Douay, Corinne, Baque, Margaux, Lependu, Claire, Marconi, Peggy, Stiasny, Karin, Heinz, Franz X., Muetsch, Margot, Duffy, Darragh, Boddaert, Jacques, Sauce, Delphine, Toubert, Antoine, Karrer, Urs, Appay, Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818547/
https://www.ncbi.nlm.nih.gov/pubmed/35114631
http://dx.doi.org/10.1016/j.ebiom.2022.103852