Metformin induces muscle atrophy by transcriptional regulation of myostatin via HDAC6 and FoxO3a

BACKGROUND: Skeletal muscle atrophy is a severe condition that involves loss of muscle mass and quality. Drug intake can also cause muscle atrophy. Biguanide metformin is the first‐line and most widely prescribed anti‐diabetic drug for patients with type 2 diabetes. The molecular mechanism of metfor...

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Detalles Bibliográficos
Autores principales: Kang, Min Ju, Moon, Ji Wook, Lee, Jung Ok, Kim, Ji Hae, Jung, Eun Jeong, Kim, Su Jin, Oh, Joo Yeon, Wu, Sang Woo, Lee, Pu Reum, Park, Sun Hwa, Kim, Hyeon Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles: Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818615/
https://www.ncbi.nlm.nih.gov/pubmed/34725961
http://dx.doi.org/10.1002/jcsm.12833

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818615/
https://www.ncbi.nlm.nih.gov/pubmed/34725961
http://dx.doi.org/10.1002/jcsm.12833

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