AKT controls protein synthesis and oxidative metabolism via combined mTORC1 and FOXO1 signalling to govern muscle physiology

BACKGROUND: Skeletomuscular diseases result in significant muscle loss and decreased performance, paralleled by a loss in mitochondrial and oxidative capacity. Insulin and insulin‐like growth factor‐1 (IGF‐1) are two potent anabolic hormones that activate a host of signalling intermediates including...

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Detalles Bibliográficos
Autores principales: Jaiswal, Natasha, Gavin, Matthew, Loro, Emanuele, Sostre‐Colón, Jaimarie, Roberson, Paul A., Uehara, Kahealani, Rivera‐Fuentes, Nicole, Neinast, Michael, Arany, Zoltan, Kimball, Scot R., Khurana, Tejvir S., Titchenell, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles: Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818654/
https://www.ncbi.nlm.nih.gov/pubmed/34751006
http://dx.doi.org/10.1002/jcsm.12846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818654/
https://www.ncbi.nlm.nih.gov/pubmed/34751006
http://dx.doi.org/10.1002/jcsm.12846

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