GSK2606414 attenuates PERK/p-eIF2α/ATF4/CHOP axis and augments mitochondrial function to mitigate high glucose induced neurotoxicity in N2A cells

Neuronal dysfunction and subsequent apoptosis under high glucose conditions during diabetes contribute majorly to the manifestation of diabetic peripheral neuropathy (DPN). PERK (protein kinase RNA (PKR)-like ER kinase) one among the three canonical arms of unfolded protein response (UPR), is believ...

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Detalles Bibliográficos
Autores principales: Gundu, Chayanika, Arruri, Vijay Kumar, Sherkhane, Bhoomika, Khatri, Dharmendra Kumar, Singh, Shashi Bala
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819026/
https://www.ncbi.nlm.nih.gov/pubmed/35146419
http://dx.doi.org/10.1016/j.crphar.2022.100087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819026/
https://www.ncbi.nlm.nih.gov/pubmed/35146419
http://dx.doi.org/10.1016/j.crphar.2022.100087

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