Cargando…

GSK2606414 attenuates PERK/p-eIF2α/ATF4/CHOP axis and augments mitochondrial function to mitigate high glucose induced neurotoxicity in N2A cells

Neuronal dysfunction and subsequent apoptosis under high glucose conditions during diabetes contribute majorly to the manifestation of diabetic peripheral neuropathy (DPN). PERK (protein kinase RNA (PKR)-like ER kinase) one among the three canonical arms of unfolded protein response (UPR), is believ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gundu, Chayanika, Arruri, Vijay Kumar, Sherkhane, Bhoomika, Khatri, Dharmendra Kumar, Singh, Shashi Bala
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819026/ https://www.ncbi.nlm.nih.gov/pubmed/35146419 http://dx.doi.org/10.1016/j.crphar.2022.100087

Ejemplares similares

Nephroprotective potential of syringic acid in experimental diabetic nephropathy: Focus on oxidative stress and autophagy
por: Sherkhane, Bhoomika, et al.
Publicado: (2023)

The PERK Inhibitor GSK2606414 Enhances Reovirus Infection in Head and Neck Squamous Cell Carcinoma via an ATF4-Dependent Mechanism
por: McLaughlin, Martin, et al.
Publicado: (2020)

PERK‐eIF2α‐ATF4‐CHOP Signaling Contributes to TNFα‐Induced Vascular Calcification
por: Masuda, Masashi, et al.
Publicado: (2013)

Collagenase-Responsive Hydrogel Loaded with GSK2606414 Nanoparticles for Periodontitis Treatment through Inhibiting Inflammation-Induced Expression of PERK of Periodontal Ligament Stem Cells
por: Zhou, Yuchen, et al.
Publicado: (2023)

Sinulariolide Induced Hepatocellular Carcinoma Apoptosis through Activation of Mitochondrial-Related Apoptotic and PERK/eIF2α/ATF4/CHOP Pathway
por: Chen, Yi-Jen, et al.
Publicado: (2013)

Argininosuccinate synthase 1 suppresses tumor progression through activation of PERK/eIF2α/ATF4/CHOP axis in hepatocellular carcinoma
por: Kim, Sanghwa, et al.
Publicado: (2021)

The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors
por: Mahameed, Mohamed, et al.
Publicado: (2019)

Lobaplatin promotes (125)I-induced apoptosis and inhibition of proliferation in hepatocellular carcinoma by upregulating PERK-eIF2α-ATF4-CHOP pathway
por: Li, Dong, et al.
Publicado: (2019)

Resveratrol‑mediated activation of SIRT1 inhibits the PERK‑eIF2α‑ATF4 pathway and mitigates bupivacaine‑induced neurotoxicity in PC12 cells
por: Luo, Yunpeng, et al.
Publicado: (2023)

Polystyrene Microplastics Induced Ovarian Toxicity in Juvenile Rats Associated with Oxidative Stress and Activation of the PERK-eIF2α-ATF4-CHOP Signaling Pathway
por: Wang, Wanzhen, et al.
Publicado: (2023)

Esophageal cancer stem cells reduce hypoxia-induced apoptosis by inhibiting the GRP78-perk-eIF2α-ATF4-CHOP pathway in vitro
por: Lin, Ruijiang, et al.
Publicado: (2023)

Emerging Role for the PERK/eIF2α/ATF4 in Human Cutaneous Leishmaniasis
por: Dias-Teixeira, Karina Luiza, et al.
Publicado: (2017)

GSK2606414 Sensitizes ABCG2-Overexpressing Multidrug-Resistant Colorectal Cancer Cells to Chemotherapeutic Drugs
por: Yu, Ze-Zhong, et al.
Publicado: (2023)

Fuziline alleviates isoproterenol‐induced myocardial injury by inhibiting ROS‐triggered endoplasmic reticulum stress via PERK/eIF2α/ATF4/Chop pathway
por: Fan, Cai‐lian, et al.
Publicado: (2019)

PCV2 and PRV Coinfection Induces Endoplasmic Reticulum Stress via PERK-eIF2α-ATF4-CHOP and IRE1-XBP1-EDEM Pathways
por: Chen, Si, et al.
Publicado: (2022)

Inhibition of TRPA1 Ameliorates Periodontitis by Reducing Periodontal Ligament Cell Oxidative Stress and Apoptosis via PERK/eIF2α/ATF-4/CHOP Signal Pathway
por: Liu, Qian, et al.
Publicado: (2022)

Fisetin, an Anti-Inflammatory Agent, Overcomes Radioresistance by Activating the PERK-ATF4-CHOP Axis in Liver Cancer
por: Kim, Tae Woo
Publicado: (2023)

7-Acetylsinumaximol B Induces Apoptosis and Autophagy in Human Gastric Carcinoma Cells through Mitochondria Dysfunction and Activation of the PERK/eIF2α/ATF4/CHOP Signaling Pathway
por: Tsai, Tsung-Chang, et al.
Publicado: (2018)

ERH Interacts With EIF2α and Regulates the EIF2α/ATF4/CHOP Pathway in Bladder Cancer Cells
por: Pang, Kun, et al.
Publicado: (2022)

Avarol Induces Apoptosis in Pancreatic Ductal Adenocarcinoma Cells by Activating PERK–eIF2α–CHOP Signaling
por: Namba, Takushi, et al.
Publicado: (2015)

Apoptosis induced by mercuric chloride is associated with upregulation of PERK-ATF4-CHOP pathway in chicken embryonic kidney cells
por: Ma, Yan, et al.
Publicado: (2020)

Protection of catalpol against triptolide-induced hepatotoxicity by inhibiting excessive autophagy via the PERK-ATF4-CHOP pathway
por: Zhang, Linluo, et al.
Publicado: (2022)

Dynamin-Independent Mechanisms of Endocytosis and Receptor Trafficking
por: Gundu, Chayanika, et al.
Publicado: (2022)

Endoplasmic Reticulum Stress PERK-ATF4-CHOP Pathway Is Associated with Hypothalamic Neuronal Injury in Different Durations of Stress in Rats
por: Yi, Shanyong, et al.
Publicado: (2017)

The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress
por: Teske, Brian F., et al.
Publicado: (2011)

Salubrinal Regulates the Apoptosis of Adrenocortical Carcinoma Cells via the PERK/eIF2α/ATF4 Signaling Pathway
por: Wu, Lili, et al.
Publicado: (2021)

Role of the PERK-eIF2α-CHOP Signaling Pathway in the Effect of Needle Knife Therapy on Knee Joint Chondrocyte Apoptosis
por: Yang, Yong-hui, et al.
Publicado: (2019)

Saturated Fatty Acids Promote GDF15 Expression in Human Macrophages through the PERK/eIF2/CHOP Signaling Pathway
por: L’homme, Laurent, et al.
Publicado: (2020)

Melatonin Inhibits Glucose-Induced Apoptosis in Osteoblastic Cell Line Through PERK-eIF2α-ATF4 Pathway
por: Zhou, Renyi, et al.
Publicado: (2020)

Oxidized phospholipids facilitate calcific aortic valve disease by elevating ATF4 through the PERK/eIF2α axis
por: Zhu, Xiaohua, et al.
Publicado: (2023)

Valdecoxib Protects against Cell Apoptosis Induced by Endoplasmic Reticulum Stress via the Inhibition of PERK-ATF4-CHOP Pathway in Experimental Glaucoma
por: Gao, Zhaolin, et al.
Publicado: (2022)

Geraniol-Mediated Suppression of Endoplasmic Reticulum Stress Protects against Cerebral Ischemia–Reperfusion Injury via the PERK-ATF4-CHOP Pathway
por: Wu, Yu, et al.
Publicado: (2022)

PUM1 knockdown prevents tumor progression by activating the PERK/eIF2/ATF4 signaling pathway in pancreatic adenocarcinoma cells
por: Dai, Haisu, et al.
Publicado: (2019)

Nox4 Promotes RANKL-Induced Autophagy and Osteoclastogenesis via Activating ROS/PERK/eIF-2α/ATF4 Pathway
por: Sun, Jing, et al.
Publicado: (2021)

Artesunate Restrains Maturation of Dendritic Cells and Ameliorates Heart Transplantation-Induced Acute Rejection in Mice through the PERK/ATF4/CHOP Signaling Pathway
por: Chen, Yuanyang, et al.
Publicado: (2021)

HIIT and MICT attenuate high-fat diet-induced hepatic lipid accumulation and ER stress via the PERK-ATF4-CHOP signaling pathway
por: Yuan, Zhang, et al.
Publicado: (2022)

Evidence for eIF2α phosphorylation-independent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications
por: Krishnamoorthy, Jothilatha, et al.
Publicado: (2014)

Endoplasmic Reticulum Stress Response Mediated by the PERK-eIF2α-ATF4 Pathway Is Involved in Osteoblast Differentiation Induced by BMP2
por: Saito, Atsushi, et al.
Publicado: (2011)

NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK–eIF2α–ATF4 signalling in breast cancer
por: Gupta, A, et al.
Publicado: (2016)

The Effects of Puerarin on Autophagy Through Regulating of the PERK/eIF2α/ATF4 Signaling Pathway Influences Renal Function in Diabetic Nephropathy
por: Xu, Xiaohui, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_08p34qofsgoqda37282pdbps3a