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Thrombospondin‐1 induced programmed death‐ligand 1‐mediated immunosuppression by activating the STAT3 pathway in osteosarcoma

Thrombospondin‐1 (TSP1) is generally assumed to suppress the growth of osteosarcoma through inhibiting angiogenesis; however, it is unclear whether TSP1 could affect the antitumor immunity against osteosarcoma. We aimed to explore the immune‐related tumor‐promoting effects of TSP1 and decipher its u...

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Detalles Bibliográficos
Autores principales: Liu, Zhuochao, Wen, Junxiang, Hu, Fangqiong, Wang, Jun, Hu, Chuanzhen, Zhang, Weibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819289/
https://www.ncbi.nlm.nih.gov/pubmed/34927311
http://dx.doi.org/10.1111/cas.15237