Cargando…

Glycosylation of MUC6 by α1,4‐linked N‐acetylglucosamine enhances suppression of pancreatic cancer malignancy

Biomarkers for early diagnosis of pancreatic cancer are greatly needed, as the high fatality of this cancer is in part due to delayed detection. α1,4‐linked N‐acetylglucosamine (αGlcNAc), a unique O‐glycan specific to gastric gland mucus, is biosynthesized by α1,4‐N‐acetylglucosaminyltransferase (α4...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yuki, Atsuko, Fujii, Chifumi, Yamanoi, Kazuhiro, Matoba, Hisanori, Harumiya, Satoru, Kawakubo, Masatomo, Nakayama, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819301/ https://www.ncbi.nlm.nih.gov/pubmed/34808019 http://dx.doi.org/10.1111/cas.15209

Ejemplares similares

α1,4‐Linked N‐acetylglucosamine suppresses gastric cancer development by inhibiting Mucin‐1‐mediated signaling
por: Fujii, Chifumi, et al.
Publicado: (2022)

Decreased alpha‐1,4‐linked N‐acetylglucosamine glycosylation in biliary tract cancer progression from biliary intraepithelial neoplasia to invasive adenocarcinoma
por: Okumura, Motohiro, et al.
Publicado: (2020)

Gastric gland mucin‐specific O‐glycan expression decreases with tumor progression from precursor lesions to pancreatic cancer
por: Ohya, Ayumi, et al.
Publicado: (2017)

Overexpression and altered glycosylation of MUC1 in malignant mesothelioma
por: Creaney, J, et al.
Publicado: (2008)

Hypoxic regulation of glycosylation via the N-acetylglucosamine cycle
por: Shirato, Ken, et al.
Publicado: (2011)

O-linked N-acetylglucosamine transferase (OGT) is overexpressed and promotes O-linked protein glycosylation in esophageal squamous cell carcinoma
por: Qiao, Zhe, et al.
Publicado: (2012)

Functional Consequences of Differential O-glycosylation of MUC1, MUC4, and MUC16 (Downstream Effects on Signaling)
por: Hanson, Ryan L., et al.
Publicado: (2016)

MUC1 Vaccines, Comprised of Glycosylated or Non-Glycosylated Peptides or Tumor-Derived MUC1, Can Circumvent Immunoediting to Control Tumor Growth in MUC1 Transgenic Mice
por: Lakshminarayanan, Vani, et al.
Publicado: (2016)

The Synthesis of UDP-N-acetylglucosamine Is Essential for Bloodstream Form Trypanosoma brucei in Vitro and in Vivo and UDP-N-acetylglucosamine Starvation Reveals a Hierarchy in Parasite Protein Glycosylation
por: Stokes, Matthew J., et al.
Publicado: (2008)

O-Linked β-N-Acetylglucosamine Modification: Linking Hypertension and the Immune System
por: dos Passos Junior, Rinaldo Rodrigues, et al.
Publicado: (2022)

O-Linked N-Acetylglucosamine Cycling Regulates Mitotic Spindle Organization
por: Tan, Ee Phie, et al.
Publicado: (2013)

Polymorphism in the intron 20 of porcine O-linked N-acetylglucosamine transferase
por: Kim, Jong Gug, et al.
Publicado: (2017)

MUC5AC and a Glycosylated Variant of MUC5B Alter Mucin Composition in Children With Acute Asthma
por: Welsh, Kathryn G., et al.
Publicado: (2017)

Cancer cell resistance to anoikis: MUC1 glycosylation comes to play
por: Yu, Lu-Gang
Publicado: (2017)

Exposure of Trypanosoma brucei to an N-acetylglucosamine-Binding Lectin Induces VSG Switching and Glycosylation Defects Resulting in Reduced Infectivity
por: Castillo-Acosta, Víctor M., et al.
Publicado: (2015)

N-Acetylglucosamine: Production and Applications
por: Chen, Jeen-Kuan, et al.
Publicado: (2010)

O-linked N-acetylglucosamine glycosylation of p65 aggravated the inflammation in both fibroblast-like synoviocytes stimulated by tumor necrosis factor-α and mice with collagen induced arthritis
por: Kim, Han Byeol, et al.
Publicado: (2015)

MUC1 O-glycosylation contributes to anoikis resistance in epithelial cancer cells
por: Piyush, Tushar, et al.
Publicado: (2017)

A Direct Method for β-Selective Glycosylation with an N-Acetylglucosamine Donor Armed by a 4-O-TBDMS Protecting Group
por: Tanaka, Hidenori, et al.
Publicado: (2017)

Nuclear pore complex glycoproteins contain cytoplasmically disposed O- linked N-acetylglucosamine
Publicado: (1987)

O-Linked N-Acetylglucosamine Transiently Elevates in HeLa Cells during Mitosis
por: Fisi, Viktória, et al.
Publicado: (2018)

Overview of the Assays to Probe O-Linked β-N-Acetylglucosamine Transferase Binding and Activity
por: Balsollier, Cyril, et al.
Publicado: (2021)

Role of O‐linked N‐acetylglucosamine in the homeostasis of metabolic organs, and its potential links with diabetes and its complications
por: Morino, Katsutaro, et al.
Publicado: (2020)

N-Acetylglucosamine Functions in Cell Signaling
por: Konopka, James B.
Publicado: (2012)

Absence of N-Acetylglucosamine Glycosylation on Listeria monocytogenes Wall Teichoic Acids Promotes Fatty Acid Tolerance by Repulsion From the Bacterial Surface
por: Thomasen, Rikke S. S., et al.
Publicado: (2022)

The involvement of beta-1,4-galactosyltransferase and N-acetylglucosamine residues in fertilization has been lost in the horse
por: Mugnier, Sylvie, et al.
Publicado: (2008)

An in vitro assay for enzymatic studies on human ALG13/14 heterodimeric UDP-N-acetylglucosamine transferase
por: Wang, Chun-Di, et al.
Publicado: (2022)

The non-glycosylated protein of Toxocara canis MUC-1 interacts with proteins of murine macrophages
por: Zhou, Rongqiong, et al.
Publicado: (2022)

Mutations in N-acetylglucosamine (O-GlcNAc) transferase in patients with X-linked intellectual disability
por: Willems, Anke P., et al.
Publicado: (2017)

A study of the structural properties of sites modified by the O-linked 6-N-acetylglucosamine transferase
por: Britto-Borges, Thiago, et al.
Publicado: (2017)

O-linked N-acetylglucosamine transferase is involved in fine regulation of flowering time in winter wheat
por: Fan, Min, et al.
Publicado: (2021)

O-linked N-acetylglucosamine transferase (OGT) regulates pancreatic α-cell function in mice
por: Essawy, Ahmad, et al.
Publicado: (2021)

Disruption of O-Linked N-Acetylglucosamine Signaling in Placenta Induces Insulin Sensitivity in Female Offspring
por: Moore, Mackenzie, et al.
Publicado: (2021)

Comparative ligand structural analytics illustrated on variably glycosylated MUC1 antigen–antibody binding
por: Barnett, Christopher B, et al.
Publicado: (2020)

Acute infection with Brachyspira hyodysenteriae affects mucin expression, glycosylation, and fecal MUC5AC
por: Lin, Susanne Je-Han, et al.
Publicado: (2023)

Molecular Characterization of the N-Acetylglucosamine Catabolic Genes in Candida africana, a Natural N-Acetylglucosamine Kinase (HXK1) Mutant
por: Felice, Maria Rosa, et al.
Publicado: (2016)

Enhancement of O-linked N-acetylglucosamine modification promotes metastasis in patients with colorectal cancer and concurrent type 2 diabetes mellitus
por: Naka, Yutaka, et al.
Publicado: (2020)

Detection of O-Linked-N-Acetylglucosamine Modification and Its Associated Enzymes in Human Degenerated Intervertebral Discs
por: Nikolaou, Georgios, et al.
Publicado: (2017)

Correction: A study of the structural properties of sites modified by the O-linked 6-N-acetylglucosamine transferase
por: Britto-Borges, Thiago, et al.
Publicado: (2017)

Epigenetic activation of O-linked β-N-acetylglucosamine transferase overrides the differentiation blockage in acute leukemia
por: Kampa-Schittenhelm, K.M., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_suko8j8foqhj5d84rmufq27klj