Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix‐mediated tumor cell adaptation and tolerance to BRAF‐targeted therapy in melanoma

Resistance to BRAF/MEK inhibitor therapy in BRAF(V600)‐mutated advanced melanoma remains a major obstacle that limits patient benefit. Microenvironment components including the extracellular matrix (ECM) can support tumor cell adaptation and tolerance to targeted therapy; however, the underlying mec...

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Detalles Bibliográficos
Autores principales: Berestjuk, Ilona, Lecacheur, Margaux, Carminati, Alexandrine, Diazzi, Serena, Rovera, Christopher, Prod’homme, Virginie, Ohanna, Mickael, Popovic, Ana, Mallavialle, Aude, Larbret, Frédéric, Pisano, Sabrina, Audebert, Stéphane, Passeron, Thierry, Gaggioli, Cédric, Girard, Christophe A, Deckert, Marcel, Tartare‐Deckert, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819497/
https://www.ncbi.nlm.nih.gov/pubmed/34957688
http://dx.doi.org/10.15252/emmm.201911814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819497/
https://www.ncbi.nlm.nih.gov/pubmed/34957688
http://dx.doi.org/10.15252/emmm.201911814

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