Enhanced Transgene Expression by Optimization of Poly A in Transfected CHO Cells

The generation of the stable, high-level recombinant protein-producing cell lines remains a significant challenge in the biopharmaceutical industry. Expression vector optimization is an effective strategy to increase transgene expression levels and stability, and the choice of suitable poly A elemen...

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Detalles Bibliográficos
Autores principales: Wang, Xiao-yin, Du, Qiu-jie, Zhang, Wei-li, Xu, Dan-hua, Zhang, Xi, Jia, Yan-long, Wang, Tian-yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819543/
https://www.ncbi.nlm.nih.gov/pubmed/35141210
http://dx.doi.org/10.3389/fbioe.2022.722722

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819543/
https://www.ncbi.nlm.nih.gov/pubmed/35141210
http://dx.doi.org/10.3389/fbioe.2022.722722

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