Dual CRISPR interference and activation for targeted reactivation of X-linked endogenous FOXP3 in human breast cancer cells

BACKGROUND: Unlike autosomal tumor suppressors, X-linked tumor suppressors can be inactivated by a single hit due to X-chromosome inactivation (XCI). Here, we argue that targeted reactivation of the non-mutated allele from XCI offers a potential therapy for female breast cancers. METHODS: Towards th...

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Detalles Bibliográficos
Autores principales: Cui, Xuelian, Zhang, Chao, Xu, Zhifang, Wang, Shuaibin, Li, Xin, Stringer-Reasor, Erica, Bae, Sejong, Zeng, Leiping, Zhao, Dehua, Liu, Runhua, Qi, Lei S., Wang, Lizhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819949/
https://www.ncbi.nlm.nih.gov/pubmed/35130925
http://dx.doi.org/10.1186/s12943-021-01472-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819949/
https://www.ncbi.nlm.nih.gov/pubmed/35130925
http://dx.doi.org/10.1186/s12943-021-01472-x

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