A proximity-based in silico approach to identify redox-labile disulfide bonds: The example of FVIII

Allosteric disulfide bonds permit highly responsive, transient ‘switch-like’ properties that are ideal for processes like coagulation and inflammation that require rapid and localised responses to damage or injury. Haemophilia A (HA) is a rare bleeding disorder managed with exogenous coagulation fac...

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Detalles Bibliográficos
Autores principales: Arsiccio, Andrea, Metcalfe, Clive, Pisano, Roberto, Raut, Sanj, Coxon, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820644/
https://www.ncbi.nlm.nih.gov/pubmed/35130281
http://dx.doi.org/10.1371/journal.pone.0262409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820644/
https://www.ncbi.nlm.nih.gov/pubmed/35130281
http://dx.doi.org/10.1371/journal.pone.0262409

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