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A proximity-based in silico approach to identify redox-labile disulfide bonds: The example of FVIII
Allosteric disulfide bonds permit highly responsive, transient ‘switch-like’ properties that are ideal for processes like coagulation and inflammation that require rapid and localised responses to damage or injury. Haemophilia A (HA) is a rare bleeding disorder managed with exogenous coagulation fac...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820644/ https://www.ncbi.nlm.nih.gov/pubmed/35130281 http://dx.doi.org/10.1371/journal.pone.0262409 |