Cargando…

Dose-dependent thresholds of dexamethasone destabilize CAR T-cell treatment efficacy

Chimeric antigen receptor (CAR) T-cell therapy is potentially an effective targeted immunotherapy for glioblastoma, yet there is presently little known about the efficacy of CAR T-cell treatment when combined with the widely used anti-inflammatory and immunosuppressant glucocorticoid, dexamethasone....

Descripción completa

Detalles Bibliográficos
Autores principales:	Brummer, Alexander B., Yang, Xin, Ma, Eric, Gutova, Margarita, Brown, Christine E., Rockne, Russell C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820647/ https://www.ncbi.nlm.nih.gov/pubmed/35081104 http://dx.doi.org/10.1371/journal.pcbi.1009504

Ejemplares similares

Data driven model discovery and interpretation for CAR T-cell killing using sparse identification and latent variables
por: Brummer, Alexander B., et al.
Publicado: (2023)

Mathematical deconvolution of CAR T-cell proliferation and exhaustion from real-time killing assay data
por: Sahoo, Prativa, et al.
Publicado: (2020)

Modeling interaction of Glioma cells and CAR T-cells considering multiple CAR T-cells bindings
por: Li, Runpeng, et al.
Publicado: (2023)

Mathematical modeling of therapeutic neural stem cell migration in mouse brain with and without brain tumors
por: Gomez, Justin, et al.
Publicado: (2022)

Repeatability of tumor perfusion kinetics from dynamic contrast-enhanced MRI in glioblastoma
por: Woodall, Ryan T, et al.
Publicado: (2021)

Long-term stability and computational analysis of migration patterns of L-MYC immortalized neural stem cells in the brain
por: Rockne, Russell C., et al.
Publicado: (2018)

Early Changes in Tumor Perfusion from T1-Weighted Dynamic Contrast-Enhanced MRI following Neural Stem Cell-Mediated Therapy of Recurrent High-Grade Glioma Correlate with Overall Survival
por: Sahoo, Prativa, et al.
Publicado: (2018)

Cortisol suppression and hearing thresholds in tinnitus after low-dose dexamethasone challenge
por: Simoens, Veerle L, et al.
Publicado: (2012)

Neuroprotective potential of intranasally delivered L-myc immortalized human neural stem cells in female rats after a controlled cortical impact injury
por: Amirbekyan, Mari, et al.
Publicado: (2023)

Neuroprotective potential of intranasally delivered L-myc immortalized human neural stem cells in female rats after a controlled cortical impact injury
por: Amirbekyan, Mari, et al.
Publicado: (2023)

Intranasally Administered L-Myc-Immortalized Human Neural Stem Cells Migrate to Primary and Distal Sites of Damage after Cortical Impact and Enhance Spatial Learning
por: Gutova, Margarita, et al.
Publicado: (2021)

Quantitative Evaluation of Intraventricular Delivery of Therapeutic Neural Stem Cells to Orthotopic Glioma
por: Gutova, Margarita, et al.
Publicado: (2019)

Human Neural Stem Cell Biodistribution and Predicted Tumor Coverage by a Diffusible Therapeutic in a Mouse Glioma Model
por: Barish, Michael E., et al.
Publicado: (2017)

Sequential CAR T cell and targeted alpha immunotherapy in disseminated multiple myeloma
por: Awuah, Dennis, et al.
Publicado: (2023)

Usefulness of cortisol/ACTH ratio (CAR) for diagnosis of cushing's syndrome: comparison of CAR with findings in dexamethasone suppression test
por: Iwamoto, Yuichiro, et al.
Publicado: (2022)

Sleep-dependent reconsolidation after memory destabilization in starlings
por: Brawn, Timothy P., et al.
Publicado: (2018)

Transcriptome Responses to Dexamethasone Depending on Dose and Glucocorticoid Receptor Sensitivity in the Liver
por: Murani, Eduard, et al.
Publicado: (2019)

Antiemetic efficacy of high-dose dexamethasone: randomized, double-blind, crossover study with a combination of dexamethasone, metoclopramide and diphenhydramine.
por: al-Idrissi, H. Y., et al.
Publicado: (1988)

Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction
por: Flavell, Charlotte R., et al.
Publicado: (2013)

Gamma analysis dependence on specified low‐dose thresholds for VMAT QA
por: Song, Ji‐Hye, et al.
Publicado: (2015)

Acute pharmacological degradation of Helios destabilizes regulatory T cells
por: Wang, Eric S., et al.
Publicado: (2021)

The Destabilization of Domestic Psychiatry
por: EIGEN, JOEL
Publicado: (2007)

Dexamethasone counteracts hepatic inflammation and oxidative stress in cholestatic rats via CAR activation
por: Gabbia, Daniela, et al.
Publicado: (2018)

Intracellular Context Affects Levels of a Chemically Dependent Destabilizing Domain
por: Sellmyer, Mark A., et al.
Publicado: (2012)

Isoflurane Reversibly Destabilizes Hippocampal Dendritic Spines by an Actin-Dependent Mechanism
por: Platholi, Jimcy, et al.
Publicado: (2014)

Spectroscopic and Simulation Studies of the Sequence-Dependent DNA Destabilization by a Fungicide
por: Sarkar, Sunipa, et al.
Publicado: (2021)

Single-molecule imaging reveals translation-dependent destabilization of mRNAs
por: Dave, Pratik, et al.
Publicado: (2023)

MON-187 Prevalence and Assessment of Overnight Dexamethasone Suppression Tests for Screening Endogenous Hypercortisolism When Serum Dexamethasone Is Below Threshold
por: Farinelli, Denise Genaro, et al.
Publicado: (2020)

Enhanced tumor accumulation and therapeutic efficacy of liposomal drugs through over-threshold dosing
por: Ao, Hui, et al.
Publicado: (2022)

CRASH-IT Switch Enables Reversible and Dose-Dependent Control of TCR and CAR T-cell Function
por: Sahillioglu, Ali Can, et al.
Publicado: (2021)

The efficacy and safety of multiple versus single doses dexamethasone in unicompartmental knee arthroplasty: A protocol of randomized controlled trial
por: Gao, Dehong, et al.
Publicado: (2020)

CAR density influences antitumoral efficacy of BCMA CAR T cells and correlates with clinical outcome
por: Rodriguez-Marquez, Paula, et al.
Publicado: (2022)

No threshold dose for micronuclei induction?
por: Diehl-Marshall, I, et al.
Publicado: (1981)

Epidural methadone results in dose-dependent analgesia in cancer pain, further enhanced by epidural dexamethasone
por: Lauretti, G R, et al.
Publicado: (2013)

Emulsion Destabilization by Squeeze Flow
por: Dekker, Riande I., et al.
Publicado: (2020)

Silent Synapses Dictate Cocaine Memory Destabilization and Reconsolidation
por: Wright, William J., et al.
Publicado: (2019)

Next frontiers in CAR T-cell therapy
por: Brown, Christine E, et al.
Publicado: (2016)

A Destabilized Case of Stable Effort Angina Pectoris Induced by Low-dose Adenosine Triphosphate
por: Sueta, Daisuke, et al.
Publicado: (2016)

LBODP082 Thresholds For Normal In Low Dose Cortrosyn Stimulation Depends On Assay Type
por: Lutz, Natalie Linn Larson, et al.
Publicado: (2022)

Comparison of Efficacy and Safety of Low-Dose Versus High-Dose Dexamethasone in Hospitalized COVID-19 Patients: A Meta-Analysis
por: Waheed, Muhammad Daniyal, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_b520fpbo11dfnsqvrqnb4qtsc7