Pharmacological Inhibition of Factor XIIa Attenuates Abdominal Aortic Aneurysm, Reduces Atherosclerosis, and Stabilizes Atherosclerotic Plaques

Background  3F7 is a monoclonal antibody targeting the enzymatic pocket of activated factor XII (FXIIa), thereby inhibiting its catalytic activity. Given the emerging role of FXIIa in promoting thromboinflammation, along with its apparent redundancy for hemostasis, the selective inhibition of FXIIa...

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Detalles Bibliográficos
Autores principales: Searle, Amy K., Chen, Yung-Chih, Wallert, Maria, McFadyen, James D., Maluenda, Ana C., Noonan, Jonathan, Kanellakis, Peter, Zaldivia, Maria T. K., Huang, Angela, Lioe, Hadi, Biondo, Mark, Nolte, Marc W., Rossato, Paolo, Bobik, Alex, Panousis, Con, Wang, Xiaowei, Hosseini, Hamid, Peter, Karlheinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820844/
https://www.ncbi.nlm.nih.gov/pubmed/34619795
http://dx.doi.org/10.1055/a-1663-8208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820844/
https://www.ncbi.nlm.nih.gov/pubmed/34619795
http://dx.doi.org/10.1055/a-1663-8208

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