Clinical and Molecular Characterization of POLE Mutations as Predictive Biomarkers of Response to Immune Checkpoint Inhibitors in Advanced Cancers

PURPOSE: DNA polymerase epsilon is critical to DNA proofreading and replication. Mutations in POLE have been associated with hypermutated tumors and antitumor response to immune checkpoint inhibitor (ICI) therapy. We present a clinicopathologic analysis of patients with advanced cancers harboring PO...

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Detalles Bibliográficos
Autores principales: Garmezy, Benjamin, Gheeya, Jinesh, Lin, Heather Y., Huang, Yuefan, Kim, Taebeom, Jiang, Xianli, Thein, Kyaw Z., Pilié, Patrick G., Zeineddine, Fadl, Wang, Wanlin, Shaw, Kenna R., Rodon, Jordi, Shen, John Paul, Yuan, Ying, Meric-Bernstam, Funda, Chen, Ken, Yap, Timothy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2022
Materias:
Original Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820927/
https://www.ncbi.nlm.nih.gov/pubmed/35108036
http://dx.doi.org/10.1200/PO.21.00267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820927/
https://www.ncbi.nlm.nih.gov/pubmed/35108036
http://dx.doi.org/10.1200/PO.21.00267

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