Biomarkers of DNA Damage Response Enable Flow Cytometry-Based Diagnostic to Identify Inborn DNA Repair Defects in Primary Immunodeficiencies

DNA damage is a constant event in every cell caused by exogenous factors such as ultraviolet and ionizing radiation (UVR/IR) and intercalating drugs, or endogenous metabolic and replicative stress. Proteins of the DNA damage response (DDR) network sense DNA lesions and induce cell cycle arrest, DNA...

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Detalles Bibliográficos
Autores principales: Felgentreff, Kerstin, Baumann, Ulrich, Klemann, Christian, Schuetz, Catharina, Viemann, Dorothee, Wetzke, Martin, Pannicke, Ulrich, von Hardenberg, Sandra, Auber, Bernd, Debatin, Klaus-Michael, Jacobsen, Eva-Maria, Hoenig, Manfred, Schulz, Ansgar, Schwarz, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8821069/
https://www.ncbi.nlm.nih.gov/pubmed/34716846
http://dx.doi.org/10.1007/s10875-021-01156-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8821069/
https://www.ncbi.nlm.nih.gov/pubmed/34716846
http://dx.doi.org/10.1007/s10875-021-01156-7

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