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Biomarkers of DNA Damage Response Enable Flow Cytometry-Based Diagnostic to Identify Inborn DNA Repair Defects in Primary Immunodeficiencies
DNA damage is a constant event in every cell caused by exogenous factors such as ultraviolet and ionizing radiation (UVR/IR) and intercalating drugs, or endogenous metabolic and replicative stress. Proteins of the DNA damage response (DDR) network sense DNA lesions and induce cell cycle arrest, DNA...
Autores principales: | Felgentreff, Kerstin, Baumann, Ulrich, Klemann, Christian, Schuetz, Catharina, Viemann, Dorothee, Wetzke, Martin, Pannicke, Ulrich, von Hardenberg, Sandra, Auber, Bernd, Debatin, Klaus-Michael, Jacobsen, Eva-Maria, Hoenig, Manfred, Schulz, Ansgar, Schwarz, Klaus |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8821069/ https://www.ncbi.nlm.nih.gov/pubmed/34716846 http://dx.doi.org/10.1007/s10875-021-01156-7 |
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