Presynaptic NMDARs on spinal nociceptor terminals state-dependently modulate synaptic transmission and pain

Postsynaptic NMDARs at spinal synapses are required for postsynaptic long-term potentiation and chronic pain. However, how presynaptic NMDARs (PreNMDARs) in spinal nociceptor terminals control presynaptic plasticity and pain hypersensitivity has remained unclear. Here we report that PreNMDARs in spi...

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Detalles Bibliográficos
Autores principales: Xie, Rou-Gang, Chu, Wen-Guang, Liu, Da-Lu, Wang, Xu, Ma, Sui-Bin, Wang, Fei, Wang, Fu-Dong, Lin, Zhen, Wu, Wen-Bin, Lu, Na, Liu, Ying-Ying, Han, Wen-Juan, Zhang, Hui, Bai, Zhan-Tao, Hu, San-Jue, Tao, Hui-Ren, Kuner, Thomas, Zhang, Xu, Kuner, Rohini, Wu, Sheng-Xi, Luo, Ceng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8821657/
https://www.ncbi.nlm.nih.gov/pubmed/35132099
http://dx.doi.org/10.1038/s41467-022-28429-y

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