Pulmonary Delivery of Aerosolized Chloroquine and Hydroxychloroquine to Treat COVID-19: In Vitro Experimentation to Human Dosing Predictions

In vitro screening for pharmacological activity of existing drugs showed chloroquine and hydroxychloroquine to be effective against severe acute respiratory syndrome coronavirus 2. Oral administration of these compounds to obtain desired pulmonary exposures resulted in dose-limiting systemic toxicit...

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Detalles Bibliográficos
Autores principales: Kolli, Aditya R., Semren, Tanja Zivkovic, Bovard, David, Majeed, Shoaib, van der Toorn, Marco, Scheuner, Sophie, Guy, Philippe A., Kuczaj, Arkadiusz, Mazurov, Anatoly, Frentzel, Stefan, Calvino-Martin, Florian, Ivanov, Nikolai V., O’Mullane, John, Peitsch, Manuel C., Hoeng, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8821864/
https://www.ncbi.nlm.nih.gov/pubmed/35132508
http://dx.doi.org/10.1208/s12248-021-00666-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8821864/
https://www.ncbi.nlm.nih.gov/pubmed/35132508
http://dx.doi.org/10.1208/s12248-021-00666-x

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