A chemokine regulatory loop induces cholesterol synthesis in lung-colonizing triple-negative breast cancer cells to fuel metastatic growth

Triple-negative breast cancer (TNBC) has a high propensity for organ-specific metastasis. However, the underlying mechanisms are not well understood. Here we show that the primary TNBC tumor-derived C-X-C motif chemokines 1/2/8 (CXCL1/2/8) stimulate lung-resident fibroblasts to produce the C-C motif...

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Detalles Bibliográficos
Autores principales: Han, Bingchen, Alonso-Valenteen, Felix, Wang, Zhe, Deng, Nan, Lee, Tian-Yu, Gao, Bowen, Zhang, Ying, Xu, Yali, Zhang, Xinfeng, Billet, Sandrine, Fan, Xuemo, Shiao, Stephen, Bhowmick, Neil, Medina-Kauwe, Lali, Giuliano, Armando, Cui, Xiaojiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8821896/
https://www.ncbi.nlm.nih.gov/pubmed/34274535
http://dx.doi.org/10.1016/j.ymthe.2021.07.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8821896/
https://www.ncbi.nlm.nih.gov/pubmed/34274535
http://dx.doi.org/10.1016/j.ymthe.2021.07.003

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