IL12 integrated into the CAR exodomain converts CD8(+) T cells to poly-functional NK-like cells with superior killing of antigen-loss tumors

Chimeric antigen receptor (CAR)-redirected T cell therapy often fails to control tumors in the long term due to selecting cancer cells that downregulated or lost CAR targeted antigen. To reprogram the functional capacities specifically of engineered CAR T cells, we inserted IL12 into the extracellul...

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Detalles Bibliográficos
Autores principales: Hombach, Andreas, Barden, Markus, Hannappel, Lisa, Chmielewski, Markus, Rappl, Gunter, Sachinidis, Agapios, Abken, Hinrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8821972/
https://www.ncbi.nlm.nih.gov/pubmed/34678512
http://dx.doi.org/10.1016/j.ymthe.2021.10.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8821972/
https://www.ncbi.nlm.nih.gov/pubmed/34678512
http://dx.doi.org/10.1016/j.ymthe.2021.10.011

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