The independent prognostic value of global epigenetic alterations: An analysis of single-cell ATAC-seq of circulating leukocytes from trauma patients followed by validation in whole blood leukocyte transcriptomes across three etiologies of critical illness

BACKGROUND: While bulk and single cell transcriptomic patterns in circulating leukocytes from trauma patients have been reported, how these relate to changes in open chromatin patterns remain unstudied. Here, we investigated whether single-cell ATAC-seq would provide further resolution of transcript...

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Detalles Bibliográficos
Autores principales: Chen, Tianmeng, Conroy, Julia, Wang, Xinjun, Situ, Michelle, Namas, Rami A., Vodovotz, Yoram, Chen, Wei, Singh, Harinder, Billiar, Timothy R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822299/
https://www.ncbi.nlm.nih.gov/pubmed/35124428
http://dx.doi.org/10.1016/j.ebiom.2022.103860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822299/
https://www.ncbi.nlm.nih.gov/pubmed/35124428
http://dx.doi.org/10.1016/j.ebiom.2022.103860

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