Degradation of the Escherichia coli Essential Proteins DapB and Dxr Results in Oxidative Stress, which Contributes to Lethality through Incomplete Base Excision Repair

Various lethal stresses, including bactericidal antibiotics, can trigger the production of reactive oxygen species (ROS) that contribute to killing. Incomplete base excision repair (BER) of oxidized nucleotides, especially 8-oxo-dG, has been identified as a major component of ROS-induced lethality....

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Detalles Bibliográficos
Autores principales: Gruber, Charley C., Babu, Vignesh M. P., Livingston, Kamren, Joisher, Heer, Walker, Graham C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822343/
https://www.ncbi.nlm.nih.gov/pubmed/35130721
http://dx.doi.org/10.1128/mbio.03756-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822343/
https://www.ncbi.nlm.nih.gov/pubmed/35130721
http://dx.doi.org/10.1128/mbio.03756-21

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