Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions

The demands of cancer cell proliferation alongside an inadequate angiogenic response lead to insufficient oxygen availability in the tumor microenvironment. Within the mitochondria, oxygen is the major electron acceptor for NADH, with the result that the reducing potential produced through tricarbox...

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Detalles Bibliográficos
Autores principales: Westbrook, Rebecca L., Bridges, Esther, Roberts, Jennie, Escribano-Gonzalez, Cristina, Eales, Katherine L., Vettore, Lisa A., Walker, Paul D., Vera-Siguenza, Elias, Rana, Himani, Cuozzo, Federica, Eskla, Kattri-Liis, Vellama, Hans, Shaaban, Abeer, Nixon, Colin, Luuk, Hendrik, Lavery, Gareth G., Hodson, David J., Harris, Adrian L., Tennant, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822494/
https://www.ncbi.nlm.nih.gov/pubmed/35108535
http://dx.doi.org/10.1016/j.celrep.2022.110320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822494/
https://www.ncbi.nlm.nih.gov/pubmed/35108535
http://dx.doi.org/10.1016/j.celrep.2022.110320

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