Antibody bivalency improves antiviral efficacy by inhibiting virion release independently of Fc gamma receptors

Across the animal kingdom, multivalency discriminates antibodies from all other immunoglobulin superfamily members. The evolutionary forces conserving multivalency above other structural hallmarks of antibodies remain, however, incompletely defined. Here, we engineer monovalent either Fc-competent o...

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Detalles Bibliográficos
Autores principales: Sahin, Mehmet, Remy, Melissa M., Fallet, Benedict, Sommerstein, Rami, Florova, Marianna, Langner, Anna, Klausz, Katja, Straub, Tobias, Kreutzfeldt, Mario, Wagner, Ingrid, Schmidt, Cinzia T., Malinge, Pauline, Magistrelli, Giovanni, Izui, Shozo, Pircher, Hanspeter, Verbeek, J. Sjef, Merkler, Doron, Peipp, Matthias, Pinschewer, Daniel D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822495/
https://www.ncbi.nlm.nih.gov/pubmed/35108544
http://dx.doi.org/10.1016/j.celrep.2022.110303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822495/
https://www.ncbi.nlm.nih.gov/pubmed/35108544
http://dx.doi.org/10.1016/j.celrep.2022.110303

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