Structural and biological insights into Klebsiella pneumoniae surface polysaccharide degradation by a bacteriophage K1 lyase: implications for clinical use

BACKGROUND: K1 capsular polysaccharide (CPS)-associated Klebsiella pneumoniae is the primary cause of pyogenic liver abscesses (PLA) in Asia. Patients with PLA often have serious complications, ultimately leading to a mortality of ~ 5%. This K1 CPS has been reported as a promising target for develop...

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Detalles Bibliográficos
Autores principales: Tu, I-Fan, Lin, Tzu-Lung, Yang, Feng-Ling, Lee, I-Ming, Tu, Wei-Lin, Liao, Jiahn-Haur, Ko, Tzu-Ping, Wu, Wen-Jin, Jan, Jia-Tsrong, Ho, Meng-Ru, Chou, Ching-Yi, Wang, Andrew H.-J., Wu, Chung-Yi, Wang, Jin-Town, Huang, Kai-Fa, Wu, Shih-Hsiung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822698/
https://www.ncbi.nlm.nih.gov/pubmed/35130876
http://dx.doi.org/10.1186/s12929-022-00792-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822698/
https://www.ncbi.nlm.nih.gov/pubmed/35130876
http://dx.doi.org/10.1186/s12929-022-00792-4

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