PBK/TOPK inhibitor OTS964 resistance is mediated by ABCB1-dependent transport function in cancer: in vitro and in vivo study

ABCB1 overexpression significantly desensitized both drug-selected and gene-transfected cells, which overexpress ABCB1, to OTS964 and that this drug resistance can be antagonized by verapamil, a known ABCB1 inhibitor. Consistently, a similar trend was observed in tumor-bearing mice. OTS964 stimulate...

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Detalles Bibliográficos
Autores principales: Yang, Yuqi, Teng, Qiu-Xu, Wu, Zhuo-Xun, Wang, Jing-Quan, Lei, Zi-Ning, Lusvarghi, Sabrina, Ambudkar, Suresh V., Ji, Ning, Chen, Zhe-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822834/
https://www.ncbi.nlm.nih.gov/pubmed/35135547
http://dx.doi.org/10.1186/s12943-022-01512-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822834/
https://www.ncbi.nlm.nih.gov/pubmed/35135547
http://dx.doi.org/10.1186/s12943-022-01512-0

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