Cargando…

PBK/TOPK inhibitor OTS964 resistance is mediated by ABCB1-dependent transport function in cancer: in vitro and in vivo study

ABCB1 overexpression significantly desensitized both drug-selected and gene-transfected cells, which overexpress ABCB1, to OTS964 and that this drug resistance can be antagonized by verapamil, a known ABCB1 inhibitor. Consistently, a similar trend was observed in tumor-bearing mice. OTS964 stimulate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Yuqi, Teng, Qiu-Xu, Wu, Zhuo-Xun, Wang, Jing-Quan, Lei, Zi-Ning, Lusvarghi, Sabrina, Ambudkar, Suresh V., Ji, Ning, Chen, Zhe-Sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Letter to the Editor
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822834/ https://www.ncbi.nlm.nih.gov/pubmed/35135547 http://dx.doi.org/10.1186/s12943-022-01512-0

Ejemplares similares

OTS964, a TOPK Inhibitor, Is Susceptible to ABCG2-Mediated Drug Resistance
por: Yang, Yuqi, et al.
Publicado: (2021)

PBK/TOPK Inhibitor Suppresses the Progression of Prolactinomas
por: Zhu, Kejing, et al.
Publicado: (2022)

PBK/TOPK Expression Predicts Prognosis in Oral Cancer
por: Chang, Chin-Fang, et al.
Publicado: (2016)

PBK/TOPK: A Therapeutic Target Worthy of Attention
por: Han, Ziping, et al.
Publicado: (2021)

Sitravatinib, a Tyrosine Kinase Inhibitor, Inhibits the Transport Function of ABCG2 and Restores Sensitivity to Chemotherapy-Resistant Cancer Cells in vitro
por: Yang, Yuqi, et al.
Publicado: (2020)

PBK/TOPK: An Effective Drug Target with Diverse Therapeutic Potential
por: Huang, Hai, et al.
Publicado: (2021)

Evidence for the critical role of transmembrane helices 1 and 7 in substrate transport by human P-glycoprotein (ABCB1)
por: Sajid, Andaleeb, et al.
Publicado: (2018)

PBK/TOPK mediates geranylgeranylation signaling for breast cancer cell proliferation
por: Dou, Xiaoyan, et al.
Publicado: (2015)

Use of photoimmunoconjugates to characterize ABCB1 in cancer cells
por: Liang, Barry J., et al.
Publicado: (2021)

Tivantinib, A c-Met Inhibitor in Clinical Trials, Is Susceptible to ABCG2-Mediated Drug Resistance
por: Wu, Zhuo-Xun, et al.
Publicado: (2020)

Overexpression of PBK/TOPK relates to tumour malignant potential and poor outcome of gastric carcinoma
por: Ohashi, Takuma, et al.
Publicado: (2017)

PBK/TOPK overexpression and survival in solid tumors: A PRISMA-compliant meta-analysis
por: Xu, Ming, et al.
Publicado: (2019)

PBK/TOPK Is a Favorable Prognostic Biomarker Correlated with Antitumor Immunity in Colon Cancers
por: Lee, Dong-Hee, et al.
Publicado: (2022)

Residues from Homologous Transmembrane Helices 4 and 10 Are Critical for P-Glycoprotein (ABCB1)-Mediated Drug Transport
por: Rahman, Hadiar, et al.
Publicado: (2023)

Overexpression of PBK/TOPK relates to poor prognosis of patients with breast cancer: a retrospective analysis
por: Qiao, Liang, et al.
Publicado: (2022)

Overexpression of ABCB1 Transporter Confers Resistance to mTOR Inhibitor WYE-354 in Cancer Cells
por: Wang, Jingqiu, et al.
Publicado: (2020)

TOPK/PBK is phosphorylated by ERK2 at serine 32, promotes tumorigenesis and is involved in sorafenib resistance in RCC
por: Sun, Huimin, et al.
Publicado: (2022)

The Resistance of Cancer Cells to Palbociclib, a Cyclin-Dependent Kinase 4/6 Inhibitor, is Mediated by the ABCB1 Transporter
por: Fu, Han, et al.
Publicado: (2022)

Targeting PBK/TOPK decreases growth and survival of glioma initiating cells in vitro and attenuates tumor growth in vivo
por: Joel, Mrinal, et al.
Publicado: (2015)

Prognostic Value of PDZ-Binding Kinase/T-LAK Cell-Originated Protein Kinase (PBK/TOPK) in Patients with Cancer
por: Zhang, Yi, et al.
Publicado: (2019)

Modulating the function of ABCB1: in vitro and in vivo characterization of sitravatinib, a tyrosine kinase inhibitor
por: Yang, Yuqi, et al.
Publicado: (2020)

The Protective Role of the TOPK/PBK Pathway in Myocardial Ischemia/Reperfusion and H(2)O(2)-Induced Injury in H9C2 Cardiomyocytes
por: Sun, Guozhe, et al.
Publicado: (2016)

Potent anti‐myeloma activity of the TOPK inhibitor OTS514 in pre‐clinical models
por: Stefka, Andrew T., et al.
Publicado: (2019)

Identification of the oncogenic kinase TOPK/PBK as a master mitotic regulator of C2H2 zinc finger proteins
por: Rizkallah, Raed, et al.
Publicado: (2015)

Midostaurin Reverses ABCB1-Mediated Multidrug Resistance, an in vitro Study
por: Ji, Ning, et al.
Publicado: (2019)

The combined efficacy of OTS964 and temozolomide for reducing the size of power-law coded heterogeneous glioma stem cell populations
por: Sugimori, Michiya, et al.
Publicado: (2019)

VS-4718 Antagonizes Multidrug Resistance in ABCB1- and ABCG2-Overexpressing Cancer Cells by Inhibiting the Efflux Function of ABC Transporters
por: Ji, Ning, et al.
Publicado: (2018)

PBK/TOPK enhances aggressive phenotype in prostate cancer via β-catenin-TCF/LEF-mediated matrix metalloproteinases production and invasion
por: Brown-Clay, Joshua D., et al.
Publicado: (2015)

Sapitinib Reverses Anticancer Drug Resistance in Colon Cancer Cells Overexpressing the ABCB1 Transporter
por: Gao, Hai-Ling, et al.
Publicado: (2020)

Erratum: PBK/TOPK enhances aggressive phenotype in prostate cancer via β-catenin-TCF/LEF-mediated matrix metalloproteinases production and invasion
por: Brown-Clay, Joshua D., et al.
Publicado: (2016)

Mechanistic Insights into Photodynamic Regulation of Adenosine 5′-Triphosphate-Binding Cassette Drug Transporters
por: Liang, Barry J., et al.
Publicado: (2021)

Multidrug transporters: recent insights from cryo-electron microscopy-derived atomic structures and animal models
por: Lusvarghi, Sabrina, et al.
Publicado: (2020)

Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter
por: Robey, Robert W., et al.
Publicado: (2021)

Cytoplasmic, nuclear, and total PBK/TOPK expression is associated with prognosis in colorectal cancer patients: A retrospective analysis based on immunohistochemistry stain of tissue microarrays
por: Su, Tzu-Cheng, et al.
Publicado: (2018)

The Selective Class IIa Histone Deacetylase Inhibitor TMP195 Resensitizes ABCB1- and ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Cytotoxic Anticancer Drugs
por: Wu, Chung-Pu, et al.
Publicado: (2019)

Poziotinib Inhibits the Efflux Activity of the ABCB1 and ABCG2 Transporters and the Expression of the ABCG2 Transporter Protein in Multidrug Resistant Colon Cancer Cells
por: Zhang, Yongchao, et al.
Publicado: (2020)

BMS-599626, a Highly Selective Pan-HER Kinase Inhibitor, Antagonizes ABCG2-Mediated Drug Resistance
por: Ashar, Yunali V., et al.
Publicado: (2020)

Targeting the T-Lak cell originated protein kinase by OTS964 shrinks the size of power-law coded heterogeneous glioma stem cell populations
por: Sugimori, Michiya, et al.
Publicado: (2017)

Overexpression of Human ABCB1 and ABCG2 Reduces the Susceptibility of Cancer Cells to the Histone Deacetylase 6-Specific Inhibitor Citarinostat
por: Wu, Chung-Pu, et al.
Publicado: (2021)

Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon
por: Xiao, Juanjuan, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_n49o6m4elk0fo68bulbro750ns