Gas6 induces inflammation and reduces plaque burden but worsens behavior in a sex-dependent manner in the APP/PS1 model of Alzheimer’s disease

BACKGROUND: Alzheimer’s disease is the leading cause of dementia worldwide. TAM receptor tyrosine kinases (Tyro3, Axl, MerTK) are known for their role in engagement of phagocytosis and modulation of inflammation, and recent evidence suggests a complex relationship between Axl, Mer, and microglial ph...

Descripción completa

Detalles Bibliográficos
Autores principales: Owlett, Laura D., Karaahmet, Berke, Le, Linh, Belcher, Elizabeth K., Dionisio-Santos, Dawling, Olschowka, John A., Elliott, Michael R., O’Banion, M. Kerry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822838/
https://www.ncbi.nlm.nih.gov/pubmed/35130912
http://dx.doi.org/10.1186/s12974-022-02397-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822838/
https://www.ncbi.nlm.nih.gov/pubmed/35130912
http://dx.doi.org/10.1186/s12974-022-02397-y

Ejemplares similares