4373 Defining the role of non-canonical PIK3CA mutations in head and neck squamous cell carcinoma

OBJECTIVES/GOALS: To characterize the oncogenic potential of HNSCC cell lines harboring 17 non-canonical PIK3CA mutations. METHODS/STUDY POPULATION: Non-canonical PIK3CA mutant constructs generated via site-directed mutagenesis are subcloned into doxycycline-inducible vector pLVX-Puro. Serum-depende...

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Detalles Bibliográficos
Autores principales: Lee, Michelle Ji-Eun, Jin, Nan, Cho, Janice, Kwok-shing, Patrick, Mills, Gordon B., Johnson, Daniel E., Grandis, Jennifer R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2020
Materias:
Basic Science/Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8823066/
http://dx.doi.org/10.1017/cts.2020.60

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8823066/
http://dx.doi.org/10.1017/cts.2020.60

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