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4373 Defining the role of non-canonical PIK3CA mutations in head and neck squamous cell carcinoma

OBJECTIVES/GOALS: To characterize the oncogenic potential of HNSCC cell lines harboring 17 non-canonical PIK3CA mutations. METHODS/STUDY POPULATION: Non-canonical PIK3CA mutant constructs generated via site-directed mutagenesis are subcloned into doxycycline-inducible vector pLVX-Puro. Serum-depende...

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Detalles Bibliográficos
Autores principales:	Lee, Michelle Ji-Eun, Jin, Nan, Cho, Janice, Kwok-shing, Patrick, Mills, Gordon B., Johnson, Daniel E., Grandis, Jennifer R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cambridge University Press 2020
Materias:	Basic Science/Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8823066/ http://dx.doi.org/10.1017/cts.2020.60

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