4427 Angiopoietin F-domain valency determines outcome of Tie2 receptor engagement and accelerates angiogenesis in tissue regeneration

OBJECTIVES/GOALS: Lack of blood vessels remains a major obstacle in tissue regeneration. Angiopoietin 1 and 2 modulate angiogenesis through the Tie2 receptor tyrosine kinase. Ang1 activates pAKT to promote endothelial cell survival while Ang2 antagonizes these effects. We aim to dissect the Ang/Tie2...

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Detalles Bibliográficos
Autores principales: Zhao, Yan Ting, Fallas, Jorge, Saini, Shally, Ueda, George, Somasundaram, Logeshwaran, Zhou, Ziben, Seller, Drew, Baker, David, Ruohola-Baker, Hannele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2020
Materias:
Basic Science/Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8823396/
http://dx.doi.org/10.1017/cts.2020.53

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8823396/
http://dx.doi.org/10.1017/cts.2020.53

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