Bay41-4109-induced aberrant polymers of hepatitis b capsid proteins are removed via STUB1-promoted p62-mediated macroautophagy

The hepatitis B virus (HBV) core protein (HBc) functions in multiple steps of the viral life cycle. Heteroaryldihydropyrimidine compounds (HAPs) such as Bay41-4109 are capsid protein allosteric modulators that accelerate HBc degradation and inhibit the virion secretion of HBV, specifically by mislea...

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Detalles Bibliográficos
Autores principales: Lin, Jiacheng, Yin, Limin, Xu, Xia-Zhen, Sun, He-Chen, Huang, Zhi-Hua, Ni, Xue-Yun, Chen, Yan, Lin, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824320/
https://www.ncbi.nlm.nih.gov/pubmed/35030230
http://dx.doi.org/10.1371/journal.ppat.1010204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824320/
https://www.ncbi.nlm.nih.gov/pubmed/35030230
http://dx.doi.org/10.1371/journal.ppat.1010204

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