Protein-protein interaction of RdRp with its co-factor NSP8 and NSP7 to decipher the interface hotspot residues for drug targeting: A comparison between SARS-CoV-2 and SARS-CoV

In this study we explored the molecular mechanism of RdRp (Non-Structural Protein, NSP12) interaction with its co-factors NSP7 and NSP8 which is the main toolbox for RNA replication and transcription of SARS-CoV-2 and SARS-CoV. The replication complex is a heterotetramer consists of one NSP12, one N...

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Detalles Bibliográficos
Autores principales: Sarma, Himakshi, Jamir, Esther, Sastry, G. Narahari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824464/
https://www.ncbi.nlm.nih.gov/pubmed/35153334
http://dx.doi.org/10.1016/j.molstruc.2022.132602

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824464/
https://www.ncbi.nlm.nih.gov/pubmed/35153334
http://dx.doi.org/10.1016/j.molstruc.2022.132602

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