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Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis
DNA damage response mechanisms have meiotic roles that ensure successful gamete formation. While completion of meiotic double-strand break (DSB) repair requires the canonical RAD9A-RAD1-HUS1 (9A-1-1) complex, mammalian meiocytes also express RAD9A and HUS1 paralogs, RAD9B and HUS1B, predicted to for...
Autores principales: | Pereira, Catalina, Arroyo-Martinez, Gerardo A, Guo, Matthew Z, Downey, Michael S, Kelly, Emma R, Grive, Kathryn J, Mahadevaiah, Shantha K, Sims, Jennie R, Faca, Vitor M, Tsai, Charlton, Schiltz, Carl J, Wit, Niek, Jacobs, Heinz, Clark, Nathan L, Freire, Raimundo, Turner, James, Lyndaker, Amy M, Brieno-Enriquez, Miguel A, Cohen, Paula E, Smolka, Marcus B, Weiss, Robert S |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824475/ https://www.ncbi.nlm.nih.gov/pubmed/35133274 http://dx.doi.org/10.7554/eLife.68677 |
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