A zebrafish embryo screen utilizing gastrulation identifies the HTR2C inhibitor pizotifen as a suppressor of EMT-mediated metastasis

Metastasis is responsible for approximately 90% of cancer-associated mortality but few models exist that allow for rapid and effective screening of anti-metastasis drugs. Current mouse models of metastasis are too expensive and time consuming to use for rapid and high-throughput screening. Therefore...

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Detalles Bibliográficos
Autores principales: Nakayama, Joji, Tan, Lora, Li, Yan, Goh, Boon Cher, Wang, Shu, Makinoshima, Hideki, Gong, Zhiyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824480/
https://www.ncbi.nlm.nih.gov/pubmed/34919051
http://dx.doi.org/10.7554/eLife.70151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824480/
https://www.ncbi.nlm.nih.gov/pubmed/34919051
http://dx.doi.org/10.7554/eLife.70151

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