Radiotracer stereochemistry affects substrate affinity and kinetics for improved imaging of system x(C)(-) in tumors

Amino acid utilization is perturbed in cancer cells, which rewire their metabolism to support cell survival and proliferation. This metabolic reprogramming can be exploited for diagnostic purposes through positron emission tomography imaging of fluorine-18 labeled amino acids. Despite its promise, l...

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Detalles Bibliográficos
Autores principales: Greenwood, Hannah E., Edwards, Richard, Koglin, Norman, Berndt, Mathias, Baark, Friedrich, Kim, Jana, Firth, George, Khalil, Eman, Mueller, Andre, Witney, Timothy H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8825600/
https://www.ncbi.nlm.nih.gov/pubmed/35198080
http://dx.doi.org/10.7150/thno.63237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8825600/
https://www.ncbi.nlm.nih.gov/pubmed/35198080
http://dx.doi.org/10.7150/thno.63237

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