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Radiotracer stereochemistry affects substrate affinity and kinetics for improved imaging of system x(C)(-) in tumors
Amino acid utilization is perturbed in cancer cells, which rewire their metabolism to support cell survival and proliferation. This metabolic reprogramming can be exploited for diagnostic purposes through positron emission tomography imaging of fluorine-18 labeled amino acids. Despite its promise, l...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Ivyspring International Publisher
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8825600/ https://www.ncbi.nlm.nih.gov/pubmed/35198080 http://dx.doi.org/10.7150/thno.63237 |