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Alterations in calmodulin-cardiac ryanodine receptor molecular recognition in congenital arrhythmias

Calmodulin (CaM), a ubiquitous and highly conserved Ca(2+)-sensor protein involved in the regulation of over 300 molecular targets, has been recently associated with severe forms of lethal arrhythmia. Here, we investigated how arrhythmia-associated mutations in CaM localized at the C-terminal lobe a...

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Detalles Bibliográficos
Autores principales: Dal Cortivo, Giuditta, Barracchia, Carlo Giorgio, Marino, Valerio, D’Onofrio, Mariapina, Dell’Orco, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8825638/
https://www.ncbi.nlm.nih.gov/pubmed/35133504
http://dx.doi.org/10.1007/s00018-022-04165-w