A large-scale genome and transcriptome sequencing analysis reveals the mutation landscapes induced by high-activity adenine base editors in plants

BACKGROUND: The high-activity adenine base editors (ABEs), engineered with the recently-developed tRNA adenosine deaminases (TadA8e and TadA9), show robust base editing activity but raise concerns about off-target effects. RESULTS: In this study, we perform a comprehensive evaluation of ABE8e- and A...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Shaofang, Liu, Lang, Sun, Wenxian, Zhou, Xueping, Zhou, Huanbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826654/
https://www.ncbi.nlm.nih.gov/pubmed/35139891
http://dx.doi.org/10.1186/s13059-022-02618-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826654/
https://www.ncbi.nlm.nih.gov/pubmed/35139891
http://dx.doi.org/10.1186/s13059-022-02618-w

Ejemplares similares