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Synthetic and biosynthetic methods for selective cyclisations of 4,5-epoxy alcohols to tetrahydropyrans

Tetrahydropyrans (THPs) are common structural motifs found in natural products and synthetic therapeutic molecules. In Nature these 6-membered oxygen heterocycles are often assembled via intramolecular reactions involving either oxy-Michael additions or ring opening of epoxy-alcohols. Indeed, the po...

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Detalles Bibliográficos
Autores principales: Bowen, James I., Wang, Luoyi, Crump, Matthew P., Willis, Christine L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827043/
https://www.ncbi.nlm.nih.gov/pubmed/35029626
http://dx.doi.org/10.1039/d1ob01905h