African swine fever virus I267L acts as an important virulence factor by inhibiting RNA polymerase III-RIG-I-mediated innate immunity

ASFV is a large DNA virus that is highly pathogenic in domestic pigs. How this virus is sensed by the innate immune system as well as why it is so virulent remains enigmatic. In this study, we show that the ASFV genome contains AT-rich regions that are recognized by the DNA-directed RNA polymerase I...

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Detalles Bibliográficos
Autores principales: Ran, Yong, Li, Dan, Xiong, Mei-Guang, Liu, Hua-Nan, Feng, Tao, Shi, Zheng-Wang, Li, Yu-Hui, Wu, Huang-Ning, Wang, Su-Yun, Zheng, Hai-Xue, Wang, Yan-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827485/
https://www.ncbi.nlm.nih.gov/pubmed/35089988
http://dx.doi.org/10.1371/journal.ppat.1010270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827485/
https://www.ncbi.nlm.nih.gov/pubmed/35089988
http://dx.doi.org/10.1371/journal.ppat.1010270

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