Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation

The hallmark autoantibodies in rheumatoid arthritis are characterized by variable domain glycans (VDGs). Their abundant occurrence results from the selective introduction of N-linked glycosylation sites during somatic hypermutation, and their presence is predictive for disease development. However,...

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Detalles Bibliográficos
Autores principales: Kissel, Theresa, Ge, Changrong, Hafkenscheid, Lise, Kwekkeboom, Joanneke C., Slot, Linda M., Cavallari, Marco, He, Yibo, van Schie, Karin A., Vergroesen, Rochelle D., Kampstra, Arieke S.B., Reijm, Sanne, Stoeken-Rijsbergen, Gerrie, Koeleman, Carolien, Voortman, Lennard M., Heitman, Laura H., Xu, Bingze, Pruijn, Ger J.M., Wuhrer, Manfred, Rispens, Theo, Huizinga, Tom W.J., Scherer, Hans Ulrich, Reth, Michael, Holmdahl, Rikard, Toes, Rene E.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827743/
https://www.ncbi.nlm.nih.gov/pubmed/35138894
http://dx.doi.org/10.1126/sciadv.abm1759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827743/
https://www.ncbi.nlm.nih.gov/pubmed/35138894
http://dx.doi.org/10.1126/sciadv.abm1759

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