Cargando…

52350 PKM2 mediates anti-tumor immunity and T cell dysfunction

ABSTRACT IMPACT: T cell dysfunction is a dominant suppressor of anti-tumor immunity, reducing immunotherapeutic efficacy and benefit to patients; our work will identify novel mediators of this process for both therapeutic potential and underlying mechanism, allowing for both potential immediate clin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Markowitz, Geoffrey, Ban, Yi, Crowley, Michael, Tavarez, Diamile, Wong, Stephen T.C., Chang, Kenneth, Schietinger, Andrea, Altorki, Nasser, Mittal, Vivek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cambridge University Press 2021
Materias:	Mechanistic Basic to Clinical
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827797/ http://dx.doi.org/10.1017/cts.2021.630

Ejemplares similares

Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1+ progenitor CD8+ T cells to improve checkpoint blockade
por: Markowitz, Geoffrey J., et al.
Publicado: (2023)

4581 Autonomic Dysfunction as a Marker of Depression and Coronary Artery Disease
por: Shah, Anish Sanjay
Publicado: (2020)

2372: Metabolite and biomarker predictors of WTC-lung injury: An integrated multiplatform pilot analysis
por: Crowley, George, et al.
Publicado: (2018)

4086 HIV-Associated Myocardial Diastolic Dysfunction and Soluble ST2 Concentration in Tanzanian Adults: A Cross-Sectional Study
por: Kingery, Justin, et al.
Publicado: (2020)

4311 Inflammatory biomarkers of cognitive dysfunction in pediatric obesity: associations between Executive Function, C-Reactive Protein, Interleukin 6, and Tumor Necrosis Factor alpha
por: Prendergast, Kathryn, et al.
Publicado: (2020)

2477: Biofilms in wounds: Detection, individualizing treatment and monitoring response to therapy
por: Wilder-Smith, Petra, et al.
Publicado: (2018)

2081: Phenotypic characterization of the CD4+ T-cell response during anti-CTLA4 therapy with ipilimumab in melanoma patients
por: Sherani, Farha, et al.
Publicado: (2018)

4121 The beneficial, anti-fibrotic effects of chemokine receptor 2 and 5 antagonists on fat-exposed mouse primary hepatic stellate cells (pHSCs)
por: Kruger, Annie J., et al.
Publicado: (2020)

4291 Quantifying the art of surgical decision-making in total knee arthroplasty
por: Elmasry, Shady, et al.
Publicado: (2020)

3158 Sunitinib-Induced Cardiotoxicity in an Engineered Cardiac Microtissue Model
por: Livingston, Carissa, et al.
Publicado: (2019)

3008 Role of Interferon-gamma in Natural Clearance of Chlamydia trachomatis Infection in Women
por: Jordan, Stephen, et al.
Publicado: (2019)

2392: Detecting cardiometabolic disease through breath analysis: A metabolomic approach
por: Choudary, Ahsan, et al.
Publicado: (2018)

2219: Amyotrophic lateral sclerosis, stem cells and TALENted technology
por: Kurani, Shaheen, et al.
Publicado: (2018)

2188: Implanted multijoint functional electrical stimulation assistance improves walking efficiency after stroke: A case report
por: Makowski, Nathaniel, et al.
Publicado: (2018)

2249: Gene expression signatures of acute respiratory syncytial virus infection in pediatric patients reveals insight into clinical pathogenesis
por: Dinwiddie, Darrell, et al.
Publicado: (2018)

24435 Pathogen-specific metabolic pathways and innate immune responses associated with Chlamydia trachomatis infection and other STIs
por: Ryan, John D., et al.
Publicado: (2021)

2180: hnRNP K overexpression drives acute myeloid leukemia emergence and progression
por: Hornbaker, Marisa, et al.
Publicado: (2018)

2529: Clinical determinants of clopidogrel responsiveness in a heterogeneous cohort of Caribbean Hispanics
por: Suarez, Dagmar Fredy Hernandez, et al.
Publicado: (2018)

2519: A quantitative disintegration method to evaluate polymeric films
por: Grab, Sheila, et al.
Publicado: (2018)

2370: Understanding epicardial fat biology by imaging
por: Stojanovska, Jadranka, et al.
Publicado: (2018)

3089 Clinicopathologic and Prognostic Significance of LGR5, a Cancer Stem cell Marker in Peritoneal Metastasis of a Colorectal Origin
por: Ihemelandu, Chukwuemeka
Publicado: (2019)

3280 Mycobacterium bovis Bacille-Calmette-Guérin infection aggravates atherosclerosis
por: Huaman, Moises, et al.
Publicado: (2019)

3332 Overexpression of CD44 is involved in the development of the early endometriotic lesion in a xenograft model
por: Knudtson, Jennifer, et al.
Publicado: (2019)

3127 The effect of common genetic variants in the oxytocin receptor gene on oxytocin response.
por: Malik, Manasi, et al.
Publicado: (2019)

2064: Deconstructing the peptide specificity of TCR recognition
por: Riley, Timothy P., et al.
Publicado: (2018)

3496 Mesenchymal Stem Cell Extracellular Vesicle Delivery in a Shear-Thinning Hydrogel For Therapy in an Acute Myocardial Infarction Model: A Comparative Analysis
por: Goldberg, Drew, et al.
Publicado: (2019)

3379 Associations between Diabetes Mellitus and Sublingual Microvascular Disease: A Prospective Cross-Sectional Study
por: Smilowitz, Nathaniel R, et al.
Publicado: (2019)

3559 Mechanisms of sebaceous skin microbial community remodeling through microenvironment modulation.
por: McCoy, William Howard, et al.
Publicado: (2019)

3268 A TL1 Team Approach to Personalizing Donor Human Milk for the Preterm Infant
por: Bendixen, Marion M, et al.
Publicado: (2019)

3285 Toxicity of Released B Cell Products in Multiple Sclerosis: Effects on Neurons and Oligodendrocytes
por: Zuroff, Leah, et al.
Publicado: (2019)

3424 Serial Biomarker Monitoring Predicts Long Term Outcomes in Acute Graft Versus Host Disease
por: Srinagesh, Hrishikesh Krishna, et al.
Publicado: (2019)

2399: Protective immunity to live vaccines among children with solid tumors
por: Garcia Robles, Franchesca, et al.
Publicado: (2018)

3024 Osteocyte-derived CXCL12 is Essential for Load-Induced Bone Formation in Adult Mice
por: Zuckerman, Pamela Cabahug, et al.
Publicado: (2019)

2097: Aging-associated increases in platelet granzyme A regulate pro-inflammatory gene synthesis by monocytes
por: Thomas Rondina, Matthew, et al.
Publicado: (2018)

3019 Metabolomic Markers of Methotrexate Response in Juvenile Idiopathic Arthritis
por: Funk, Ryan Sol, et al.
Publicado: (2019)

3296 Endometrial cancer microbiome biomarker for disease detection and microbial role in the disease
por: Walther-Antonio, Marina, et al.
Publicado: (2019)

2485: ETV6 represses Pax5 in early B-cell development
por: Kirkpatrick, Greg, et al.
Publicado: (2018)

3160 The Effects of Aging on the Rectal Mucosal CD4+ T cell Compartment and its Implications for HIV Transmission
por: Ackerley, Cassie Grimsley, et al.
Publicado: (2019)

2080: Therapeutic potential of mesenchymal stromal cells for hypoxic ischemic encephalopathy: A systematic review of preclinical studies
por: Moreira, Alvaro, et al.
Publicado: (2018)

2371: Perception- and behavior-related attention systems distinguished by phase amplitude coupling and high-gamma power
por: Varkki Chacko, Ravi, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_c6ku1q2lgb7dsaot62ks7j6ehb