Gain-of-Function Variant p.Pro2555Arg of von Willebrand Factor Increases Aggregate Size through Altering Stem Dynamics

The multimeric plasma glycoprotein (GP) von Willebrand factor (VWF) is best known for recruiting platelets to sites of injury during primary hemostasis. Generally, mutations in the VWF gene lead to loss of hemostatic activity and thus the bleeding disorder von Willebrand disease. By employing cone a...

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Detalles Bibliográficos
Autores principales: Huck, Volker, Chen, Po-Chia, Xu, Emma-Ruoqi, Tischer, Alexander, Klemm, Ulrike, Aponte-Santamaría, Camilo, Mess, Christian, Obser, Tobias, Kutzki, Fabian, König, Gesa, Denis, Cécile V., Gräter, Frauke, Wilmanns, Matthias, Auton, Matthew, Schneider, Stefan W., Schneppenheim, Reinhard, Hennig, Janosch, Brehm, Maria A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828397/
https://www.ncbi.nlm.nih.gov/pubmed/33385180
http://dx.doi.org/10.1055/a-1344-4405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828397/
https://www.ncbi.nlm.nih.gov/pubmed/33385180
http://dx.doi.org/10.1055/a-1344-4405

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