Suppression of ADAM8 attenuates angiotensin II-induced cardiac fibrosis and endothelial-mesenchymal transition via inhibiting TGF-β1/Smad2/Smad3 pathways

Endothelial-to-mesenchymal transition (EndMT) is involved in cardiac fibrosis induced by angiotensin II (Ang II). A disintegrin and metalloproteinase 8 (ADAM8), a member of ADAMs family, participates in cell adhesion, proteolysis and various signaling. However, its effects on the development of card...

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Detalles Bibliográficos
Autores principales: Yao, Lixia, Shao, Weihua, Chen, Yan, Wang, Suxing, Huang, Dai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Association for Laboratory Animal Science 2021
Materias:
Original
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828410/
https://www.ncbi.nlm.nih.gov/pubmed/34615811
http://dx.doi.org/10.1538/expanim.21-0064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828410/
https://www.ncbi.nlm.nih.gov/pubmed/34615811
http://dx.doi.org/10.1538/expanim.21-0064

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