Elicitation of potent SARS-CoV-2 neutralizing antibody responses through immunization with a versatile adenovirus-inspired multimerization platform

Virus-like particles (VLPs) are highly suited platforms for protein-based vaccines. In the present work, we adapted a previously designed non-infectious adenovirus-inspired 60-mer dodecahedric VLP (ADDomer) to display a multimeric array of large antigens through a SpyTag/SpyCatcher system. To valida...

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Detalles Bibliográficos
Autores principales: Chevillard, Christopher, Amen, Axelle, Besson, Solène, Hannani, Dalil, Bally, Isabelle, Dettling, Valentin, Gout, Evelyne, Moreau, Christophe J., Buisson, Marlyse, Gallet, Salomé, Fenel, Daphna, Vassal-Stermann, Emilie, Schoehn, Guy, Poignard, Pascal, Dagher, Marie-Claire, Fender, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828441/
https://www.ncbi.nlm.nih.gov/pubmed/35151843
http://dx.doi.org/10.1016/j.ymthe.2022.02.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828441/
https://www.ncbi.nlm.nih.gov/pubmed/35151843
http://dx.doi.org/10.1016/j.ymthe.2022.02.011

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