Activation mechanism of PINK1

Mutations in the protein kinase PINK1 lead to defects in mitophagy and cause autosomal recessive early onset Parkinson’s disease(1,2). PINK1 has many unique features that enable it to phosphorylate ubiquitin and the ubiquitin-like domain of Parkin(3–9). Structural analysis of PINK1 from diverse inse...

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Detalles Bibliográficos
Autores principales: Gan, Zhong Yan, Callegari, Sylvie, Cobbold, Simon A., Cotton, Thomas R., Mlodzianoski, Michael J., Schubert, Alexander F., Geoghegan, Niall D., Rogers, Kelly L., Leis, Andrew, Dewson, Grant, Glukhova, Alisa, Komander, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828467/
https://www.ncbi.nlm.nih.gov/pubmed/34933320
http://dx.doi.org/10.1038/s41586-021-04340-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828467/
https://www.ncbi.nlm.nih.gov/pubmed/34933320
http://dx.doi.org/10.1038/s41586-021-04340-2

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