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Activation mechanism of PINK1
Mutations in the protein kinase PINK1 lead to defects in mitophagy and cause autosomal recessive early onset Parkinson’s disease(1,2). PINK1 has many unique features that enable it to phosphorylate ubiquitin and the ubiquitin-like domain of Parkin(3–9). Structural analysis of PINK1 from diverse inse...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828467/ https://www.ncbi.nlm.nih.gov/pubmed/34933320 http://dx.doi.org/10.1038/s41586-021-04340-2 |