Restoration of hippocampal neural precursor function by ablation of senescent cells in the aging stem cell niche

Senescent cells are responsible, in part, for tissue decline during aging. Here, we focused on CNS neural precursor cells (NPCs) to ask if this is because senescent cells in stem cell niches impair precursor-mediated tissue maintenance. We demonstrate an aging-dependent accumulation of senescent cel...

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Detalles Bibliográficos
Autores principales: Fatt, Michael P., Tran, Lina M., Vetere, Gisella, Storer, Mekayla A., Simonetta, Jaclin V., Miller, Freda D., Frankland, Paul W., Kaplan, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828532/
https://www.ncbi.nlm.nih.gov/pubmed/35063124
http://dx.doi.org/10.1016/j.stemcr.2021.12.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828532/
https://www.ncbi.nlm.nih.gov/pubmed/35063124
http://dx.doi.org/10.1016/j.stemcr.2021.12.010

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